10/7/2023 0 Comments William cooper skull bones* pathognomonic signs 25 Plain radiograph / CT Jigsaw pattern bone or mosaic pattern bone There are many Paget disease-related signs, listed here and described in the modality-specific sections below 25: These stages correlate well with the imaging findings. Intermediate stage (active, mixed): osteoblastic as well as osteoclastic activity There are three classically described stages, which are part of a continuous spectrum 22:Įarly destructive stage (incipient active, lytic): predominated by osteoclastic activity Viral infection (paramyxovirus) 6 in association with genetic susceptibility has been postulated. The etiology is not entirely known, but it is a disease of osteoclasts. Polyostotic disease is more prevalent than monostotic type 1. The most frequent sites of involvement are: Signs and symptoms relating to complications (see below) Increased bone size: historically changing hat size was a giveaway Increased focal temperature due to bony hypervascularity (not fever) Localized pain and tenderness (most common symptom 24) The majority (approximately three-quarters) of patients are asymptomatic at the time of diagnosis, the diagnosis being an incidental finding on imaging 23. Involvement of multiple bones ( polyostotic) is more common than single or monostotic disease. It is also common in Australia, New Zealand, Western Europe, and the United States. Incidence can be considerably higher in the United Kingdom than in other countries 8. Paget disease of the bone is relatively common and can affect up to 4% of individuals over 40 and up to 11% over the age of 80 1. There may be a slight male predilection for Paget disease. Synonymous terms such as osteitis deformans, which was the name given by Paget himself to the disease, are of historical interest only. Paget disease of the bone is the most common formal name for the condition 24.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |